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Donor Updates |
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This web page is the place to find our public notice of any important updates to donor health history information that we obtain after the initial active listing for the donor is removed. We also attempt to individually notify clients that have reported success with the use of noted donors by mail or email if determined to be relevant. |
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| 099 - since his initial participation, this donor developed and was treated for testicular cancer, (the most common cancer in young men). posted 11/2006 |
| 026 - We have had a report of a donor child with growth and developmental problems that are consistant with Saethre-Chotzen Syndrome. We have received confirmation of this diagnosis, determined through clinical findings by experienced geneticists. No specific genetic testing has been done to find the exact mutation in the child. This syndrome is genetically caused, and can be passed by either parent as an autosomal dominant disease, or can be found to be "de novo" (or new) mutation. Anyone with children through the use of this donor are encouraged to become familiar with the syndromes possible traits and symptoms so that if they are found in a child, any possible treatments can be accessed as soon as possible. The donor does not display classical symptoms and knows of no biological family history in this regard, so it is currently unresolved if this donors genetic makeup is playing a direct role in this problem. If you have used this donor successfully, we would appreciate notification of any other clients recognizing problems or lack of problems of this nature with their child, and strongly encourage you to drop us an email. posted 11/27/2006 A waiver form is now available should past successful clients wish to make purchase of this donor for future use. |
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| 086 - We have had a report of one child produced through the use of this donor with Medium Chain Acyl CoA Dehydrogenase Deficiency. This is an autosomal recessive disorder, that must be passed on by both parents for disease in the child, and has an incidence rate of between one in ten to twenty thousand births in one UK study. Anyone with children through the use of this donor are encouraged to become familiar with the problem, and should be aware that any children produced through the use of this donor may be a carrier for this genetic mutation. Current information is that this disease can be highly influenced by correct recognition and treatment.(rec 12/12/06) We have not yet received confirmation of this problem through a doctors report. |
| 297 - this donor listed 11/2006 was originally mistakenly listed at a higher weight and height than was correct, and was a simple transcription error only. We apologize! The information was corrected on 11/9/2006 |
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| 425 - One client experienced a miscarriage that was later determined to show a possible genetic cause for the loss which is not uncommon. This donor has shown other success without reported similar or dissimilar problems being reported. At this time the donor has long sold out. We will post any further information as it is received. We understand that the client is proceeding with other genetic testing which may provide further information about the source of the problem. (recv'd and posted 5/2/2007) |
| 536 - By genetic relationship to donor 086, this donor is also assumed to be a carrier of the Medium Chain Acyl CoA Dehydrogenase Deficiency, MCADD. See number 086 above.(rec 12/12/06) We have had no reported problems with the use of this donor to date. |
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| 5302 - We have an (as of 5/31/07) unconfirmed report of a child with Celiac disease. The following information was obtained from a geneticist with a specialty in this disease. We do not promote the information as medical advice. Celiac disease is a disorder with a genetic link to two well known HLA molecules, DQ8 and DQ2 (with both Alpha and Beta subunits) coded for on chromosome 6. The presence of the genetic marker(s) is necessary but not sufficient for the development of the disease. In addition to the genetic predisposition, there are other factors (genetic and environmental) that contribute to the onset of celiac disease. Having one or more of the markers is extremely common (30% of the population), but having one or more of the markers in your genetic makeup does not mean that you will have the disease. Under 5% of the people that have one or more of the genetic markers will develop the disease. This risk is elevated if there is a first degree family member with confirmed celiac disease. Initial diagnosis is often made with antibody testing in symptomatic individuals and confirmatory testing is through biopsy of the intestinal tissue. The disease can be ruled out in individuals with a negative test result. Celiac disease is a chronic autoimmune disorder with multi-systemic manifestations. Ingestion of gluten-containing grains, especially wheat, can cause inflammation and damage of the small intestine. Infants with celiac disease frequently present with failure to thrive. Diets avoiding gluten are followed by those that are diagnosed. As of 6/13/2007, this report of disease in the donor child is still unconfirmed. As of 6/13/2007, we have now confirmed by DNA testing that the donor does carry the marker for the less common DQ8 molecule and half of the DQ2 molecule. This means that a child produced with this donor could be a carrier of the marker and if so would have a small chance of developing Celiac symptoms and disease, whether or not either marker is found in the mother. The donor does not have any evidence of developing the disease. Even though the donor is shown to be a carrier, it does not rule out the mother as carrier also, as one or more markers are found in 30% of the European and North American populations. Incidence for Celiac disease is only one in one hundred in the same population. This finding does not preclude the further use of this donor by clients with specimens in storage, but said clients will be notified of these findings as best we are able. For more information, please contact your physician and read up through informative web resources such as www.celiac.org/ or www.celiac.org/cd-main.php or digestive.niddk.nih.gov/ddiseases/pubs/celiac/index.htm |
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